Find data about cell viability and other cellular-level phenotypes besides gene and protein expression in response to small molecule perturbations
The Harvard Medical School (HMS) LINCS DSGC focuses on biochemical and cell-based assays that measure the response of human cells to (i) small molecule kinase inhibitors, a leading class of therapeutic agents for the treatment of cancer, autoimmune diseases, and other diseases; (ii) epigenome modifiers such as bromodomain and HDAC inhibitors; and (iii) naturally occurring ligands such as growth factors and inflammatory cytokines. Overall the Center is profiling the responses of ~100 cell lines and primary cell types to ~400 perturbagens across dose and time using multiple biochemical and cell biological assays. More information on the data, assays and protocols can be found at the HMS web portal. Access to the datasets is available through web portals and programmatically through APIs. The API access is documented here.