The Drug Toxicity Signature Generation Center links cellular drug responses to adverse events
The Drug Toxicity Signature Generation Center is a Systems Pharmacology research center at the Icahn School of Medicine. The proteomics experiments for the center are conducted at the Center for Advanced Proteomics, Rutgers-New Jersey Medical School. The overall goal of DToxS is to use genomic and proteomic high-throughput measurements coupled with medium-throughput experimental measurement of protein states as the basis for computational analysis that integrates network analyses with structural constraints and dynamical models in multiple cell types to identify signatures that predict toxicity induced by individual drugs and mitigation of this toxicity by drug combinations. To anchor the signatures in observable human disease and therapeutics, we leverage the strategy employed in our recent study, in which we searched the FDA-Adverse Event Reporting System Database (FAERS) and found nearly thousands of drug combinations used in humans where a second drug mitigates serious toxicity associated with first drug. We hypothesize that we can use these observations to improve our capability to predict toxicity of drugs and mitigation by drug pairs.