LINCS MCF10A
Molecular Deep Dive (MDD)
To develop a detailed understanding of the linkage between molecular and phenotypic changes, LINCS consortium generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB, and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and the development of novel hypotheses and computational methods. The MCF10A project was presented in a Communications Biology publication.
SigCom LINCS
Searching Over One Million Signatures
SigCom LINCS is a web-based search engine that serves over 1.5 million gene expression signatures processed, analyzed, and visualized from LINCS, GTEx, and GEO developed by BD2K-LINCS DCIC. SigCom LINCS is built from the Signature Commons framework, a cloud-agnostic generic platform that can be used to stand up Data Commons with a focus on searchable signatures. SigCom LINCS provides rapid signature similarity search for mimickers and reversers given sets of up and down genes. Additionally, users of SigCom LINCS can perform a metadata search to find and analyze subsets of signatures and find information about genes and drugs. The SigCom LINCS has been introduced as a publication in the journal Nucleic Acids Research.
LINCS MCF10A
Molecular Deep Dive (MDD)
To develop a detailed understanding of the linkage between molecular and phenotypic changes, LINCS consortium generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB, and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and the development of novel hypotheses and computational methods. The MCF10A project was presented in a Communications Biology publication.
SigCom LINCS
Searching Over One Million Signatures
SigCom LINCS is a web-based search engine that serves over 1.5 million gene expression signatures processed, analyzed, and visualized from LINCS, GTEx, and GEO developed by BD2K-LINCS DCIC. SigCom LINCS is built from the Signature Commons framework, a cloud-agnostic generic platform that can be used to stand up Data Commons with a focus on searchable signatures. SigCom LINCS provides rapid signature similarity search for mimickers and reversers given sets of up and down genes. Additionally, users of SigCom LINCS can perform a metadata search to find and analyze subsets of signatures and find information about genes and drugs. The SigCom LINCS has been introduced as a publication in the journal Nucleic Acids Research.