The Library of Integrated Network-Based Cellular Signatures (LINCS) Program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents.
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The LINCS Consortium

By generating and making public data that indicates how cells respond to various genetic and environmental stressors, the LINCS project will help us gain a more detailed understanding of cell pathways and aid efforts to develop therapies that might restore perturbed pathways and networks to their normal states. The LINCS website is a source of information for the research community and general public about the LINCS project. This website along with the LINCS Data Portal contains details about the assays, cell types, and perturbagens that are currently part of the library, as well as links to participating sites, data releases from the sites, and software that can be used for analyzing the data.

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Featured LINCS Tools

GUIdock
  • Documentation
  • Web-based
GUIdock
Docker package containing a computational environment to run apps with a GUI
SynergySeq
  • Transcript Data
  • Data Analysis
  • Data Integration
  • Signature Generation
  • Open Source
  • Web-based
SynergySeq
Identify synergistic drug combinations
slinky
  • Transcript Data
  • Data Analysis
  • Data Documentation
slinky
    R package to query the L1000 metadata via the CLUE.io REST API
    LINCS Data Portal
    • Cell State Data
    • Drug Binding Data
    • Morphology Data
    • Protein Data
    • Transcript Data
    • Data Documentation
    • Data Formatting
    • Data Integration
    • Data Storage
    • Data Visualization
    • API
    • Database
    • Documentation
    • Ontology
    • Provenance
    • Scripting
    • Search Engine
    • Versioning
    • Web-based
    LINCS Data Portal
    Provides unified interface for searching all LINCS dataset packages and entities
    Touchstone App
    • Transcript Data
    • Data Analysis
    • Data Documentation
    • Data Visualization
    • Network Analysis
    • Search Engine
    • Web-based
    Touchstone App
    Collection of CMap reference signatures
    lncHUB2
    • Cell State Data
    • Drug Binding Data
    • Morphology Data
    • Protein Data
    • Transcript Data
    • Data Analysis
    • Data Integration
    • Data Storage
    • Data Visualization
    • Signature Generation
    • API
    • Ontology
    • Open Source
    • Provenance
    • Scripting
    • Search Engine
    • Web-based
    lncHUB2
    Functional predictions of human lncRNAs based on lncRNA-gene co-expression correlations

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