The Library of Integrated Network-Based Cellular Signatures (LINCS) Program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents.
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The LINCS Consortium

By generating and making public data that indicates how cells respond to various genetic and environmental stressors, the LINCS project will help us gain a more detailed understanding of cell pathways and aid efforts to develop therapies that might restore perturbed pathways and networks to their normal states. The LINCS website is a source of information for the research community and general public about the LINCS project. This website along with the LINCS Data Portal contains details about the assays, cell types, and perturbagens that are currently part of the library, as well as links to participating sites, data releases from the sites, and software that can be used for analyzing the data.

Featured Interactive Data Visualization

Recent Publications

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Featured LINCS Tools

Appyters
  • Cell State Data
  • Morphology Data
  • Protein Data
  • Transcript Data
  • Data Analysis
  • Data Documentation
  • Data Formatting
  • Data Integration
  • Data Storage
  • Network Analysis
  • Signature Generation
  • Documentation
  • Open Source
  • Scripting
  • Web-based
Appyters
Collection of web-based applications to execute bioinformatics workflows
eXpression2Kinases
  • Cell State Data
  • Drug Binding Data
  • Protein Data
  • Transcript Data
  • Data Analysis
  • Data Integration
  • Data Visualization
  • Network Analysis
  • Signature Generation
  • API
  • Command Line
  • Database
  • Documentation
  • Open Source
  • Web-based
eXpression2Kinases
Linking expression signatures to upstream cell signaling networks
RTK Profile Browser
  • Protein Data
  • Data Visualization
  • Signature Generation
  • Documentation
  • Open Source
  • Provenance
  • Web-based
RTK Profile Browser
Online tool for browsing breast cancer cell line RTK profiles
LINCS Data Portal
  • Cell State Data
  • Drug Binding Data
  • Morphology Data
  • Protein Data
  • Transcript Data
  • Data Documentation
  • Data Formatting
  • Data Integration
  • Data Storage
  • Data Visualization
  • API
  • Database
  • Documentation
  • Ontology
  • Provenance
  • Scripting
  • Search Engine
  • Versioning
  • Web-based
LINCS Data Portal
Provides unified interface for searching all LINCS dataset packages and entities
piLINCS
  • Protein Data
  • Data Analysis
  • Data Formatting
  • Data Storage
  • Data Visualization
  • Signature Generation
  • API
  • Database
  • Search Engine
  • Versioning
  • Web-based
piLINCS
Provides interface and access to LINCS proteomics datasets available in Panorama
SigCom LINCS
  • Cell State Data
  • Drug Binding Data
  • Morphology Data
  • Protein Data
  • Transcript Data
  • Data Documentation
  • Data Formatting
  • Data Integration
  • Data Storage
  • Data Visualization
  • API
  • Database
  • Documentation
  • Ontology
  • Provenance
  • Scripting
  • Search Engine
  • Versioning
  • Web-based
SigCom LINCS
Provides unified interface for searching over one million signatures

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