Featured Interactive Data Visualization

Overview:

L1000 fireworks display (L1000FWD) is as a web application that provides interactive visualization of over 16,000 drug and small-molecule induced gene expression signatures. L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as, drug attributes such as MOA and clinical phase. The L1000FWD has been introduced in a recent publication in Bioinformatics. The LINCS Center for Transcriptomics recently published a paper in Cell describing the collection of this L1000 data. The data  used to create the visualization is available at the Gene-Expression Omnibus (GEO) accession number GSE92742, as well as, on the LINCS Data Portal (LDP).

Instructions:

L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as drug attributes such as MOA and clinical phase. Signature similarity search is implemented to enable the search for mimicking or opposing signatures given as input of up and down gene sets. Each point on the L1000FWD interactive map is linked to a signature landing page, which provides multifaceted knowledge f rom various sources about the signature and the drug. Notably such information includes most frequent diagnoses, co-prescribed drugs and age distribution of prescriptions as extracted from the Mount Sinai Health System electronic medical records (EMR). Overall, L1000FWD serves as a platform for identifying functions for novel small molecules using unsupervised clustering, as well as for exploring drug MOA.

This interactive visualization was implemented by the BD2K-LINCS DCIC (Dr. Zichen Wang, Dr. Avi Ma’ayan, and Edward He, Ma’ayan Lab, Icahn School of Medicine at Mount Sinai).